New FDA Draft Guidance: Practices to Prevent Unsafe Contamination of Animal Feed From Drug Carryover

— Written By
en Español / em Português

El inglés es el idioma de control de esta página. En la medida en que haya algún conflicto entre la traducción al inglés y la traducción, el inglés prevalece.

Al hacer clic en el enlace de traducción se activa un servicio de traducción gratuito para convertir la página al español. Al igual que con cualquier traducción por Internet, la conversión no es sensible al contexto y puede que no traduzca el texto en su significado original. NC State Extension no garantiza la exactitud del texto traducido. Por favor, tenga en cuenta que algunas aplicaciones y/o servicios pueden no funcionar como se espera cuando se traducen.


Inglês é o idioma de controle desta página. Na medida que haja algum conflito entre o texto original em Inglês e a tradução, o Inglês prevalece.

Ao clicar no link de tradução, um serviço gratuito de tradução será ativado para converter a página para o Português. Como em qualquer tradução pela internet, a conversão não é sensivel ao contexto e pode não ocorrer a tradução para o significado orginal. O serviço de Extensão da Carolina do Norte (NC State Extension) não garante a exatidão do texto traduzido. Por favor, observe que algumas funções ou serviços podem não funcionar como esperado após a tradução.


English is the controlling language of this page. To the extent there is any conflict between the English text and the translation, English controls.

Clicking on the translation link activates a free translation service to convert the page to Spanish. As with any Internet translation, the conversion is not context-sensitive and may not translate the text to its original meaning. NC State Extension does not guarantee the accuracy of the translated text. Please note that some applications and/or services may not function as expected when translated.

Collapse ▲

new draft guidance for medication carryover from FDA

The U.S. Food and Drug Administration (FDA) has released a new Draft Guidance for Industry document, GFI #272 Practices to Prevent Unsafe Contamination of Animal Feed from Drug Carryover, to replace Compliance Policy Guides 680.500, Unsafe Contamination Compliance Policy Guides of Animal Feed from Drug Carryover, and 680.600, Sequencing as a Means to Prevent Unsafe Drug Contamination in the Production, Storage, and Distribution of Feeds.

The new draft document is open for comments from industry through August 8, 2022.

Draft GFI: Practices to Prevent Unsafe Contamination of Animal Feed from Drug Carryover

The new guidance highlights acceptable practices that can be utilized in feed mills to minimize cross contamination of products when medications are being used. These techniques are useful to meet the regulatory standards for Medicated Feed Current Good Manufacturing Practice (CGMP), as well as the Current Good Manufacturing Practice, Hazard Analysis, and Risk-Based Preventive Controls for Food for Animals regulation. 

The three strategies proposed by the FDA are:

  • Physical Cleanout,
  • Flushing,
  • Sequencing, and
  • Other Equally Effective Practices.

For each of the strategies, the FDA provides relevant information for when to use each strategy and how to perform the procedure.

How can I use this information throughout my facility?

Although this new guidance document provides information on how to minimize medication carryover, the principles discussed can be applied to other scenarios as well. For example, flushing or sequencing procedures might be useful to avoid nutrient or other ingredient carryover that could lead to toxicities.

If you have any comments or suggestions for other equally effective practices for preventing drug carryover, please contact the FDA at

If you have questions about animal food safety, contact Marissa Cohen.